BANSI LAL, SURESH KUMAR, NASIR ALI, KHEMOMAL A. KARIRA, LEELA RAM, PAWAN KUMAR
ABSTRACT:
BACK GROUND AND OBJECTIVES: Free radicals, reactive oxygen species play an
important role in the pathogenesis of atherosclerosis causes Coronary Heart Disease
(CHD). Antioxidant present in our diet such as vitamin C, vitamin E and b-Carotene may
act against the free radicals. Thus they can prevent the process of atherosclerosis and
CHD. Object of this study was to determine the serum antioxidant vitamin C and lipid
profile in CHD patients.
DESIGN AND SETTING FOR STUDY: At Shaikh Zayed Hospital and Punjab Institute Of
Cardiology, Lahore.
SUBJECT AND METHODS: We have measured the Antioxidant vitamin C concentration
and lipid profile in the case controlled study of 80 patients of CHD; and 21 Healthy
Control Subjects by matching their age, sex, weight and height with respect to those of
CHD patients.
RESULTS: No significant (P> 0.05) difference was observed in the mean serum vitamin C
level in the CHD patients and control subjects. Regarding lipid profiles; significant raised
triglycerides, total cholesterol and LDL-cholesterol and significant decreased HDLcholesterol were observed when compared CHD patients with normal subjects.
CONCLUSION: No doubt nutrient oxidants are better for preventing CHD, but this study
showed no correlation between antioxidant vitamin C level and Coronary Heart Disease
(CHD). So there is need to carry out a wide study of antioxidant (Vitamin C) level in
Coronary Heart Disease.
KEY WORDS: Coronary Heart Disease (CHD), Atherosclerosis, lipid metabolism, free
Radicals, Reactive oxygen species (ROS), Oxidative stress, Antioxidants and Vitamin C.